Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) is a network of research studies looking at promising treatments for the most common symptoms of menopause. Women troubled by hot flashes and night sweats during the years around menopause want safe, effective treatment options for alleviating menopausal symptoms. To help explore these options, the National Institutes of Health established the MsFLASH research network. The MsFLASH network is conducting several randomized clinical trials to test a variety of approaches for treating menopausal symptoms, including use of anti-depressant medications, yoga, omega-3 supplementation, low dose estrogen, and exercise. Participants in the MsFLASH studies are women aged 40-62 who live in one of the areas where the five MsFLASH research centers are located: Boston, Indianapolis, Oakland, Philadelphia and Seattle. We have completed enrollment in the first two MsFLASH trials and are now enrolling women into the third study. This study will examine the effectiveness of low dose estrogen and venlafaxine, a serotonin-based medication commonly prescribed for alleviating menopausal symptoms, including hot flashes, anxiety, and mood. The following MsFLASH centers are participating in this study: Boston, Philadelphia, and Seattle.